Recordings

Jon Stevens (AbbVie, Inc.) - Ask ARCH: LLM Question Answering over Large-Scale Knowledge Graphs

138 views
June 14, 2024

Ask ARCH: LLM Question Answering over Large-Scale Knowledge Graphs
Jon Stevens (AbbVie, Inc.)

Knowledge graphs provide a vehicle for grounding LLM answers in harmonized structured data, reducing hallucinations and allowing easy fact-checking. In turn, LLMs provide a natural way for end users to query knowledge graph data, without requiring a query language or deep understanding of database structure. We present our integration of AbbVie's 30-million-node R&D knowledge graph, the ARCH Graph, with GPT-based LLMs to create a scientific question-answering system. The ARCH Graph is a Neo4J graph that harmonizes and connects molecules, drugs, genes, health conditions, and other entities from a variety of data sources, allowing scientists to make connections between disparate data points. However, querying the graph can be challenging for end users without a natural language interface. The new Ask ARCH Graph provides such an interface, allowing users to ask questions in natural language (e.g., "What genetic markers are associated with acute myeloid leukemia?") and receive natural language answers ("Some genetic markers associated with acute myeloid leukemia include PICALM (ENSG00000073921), CEBPA (ENSG00000245848), ...") along with the underlying data and the Cypher query used to retrieve it. To achieve this, the system utilizes a combination of vector search, Cypher query generation and validation, and LLM-based summarization of the Cypher output. The process of accurately retrieving information from a large-scale knowledge graph is more complex and less researched than simpler RAG methods on document corpora. We discuss the evolution of our approach and evaluate its accuracy and performance. The integration of LLMs with knowledge graphs helps reduce hallucinations, improve reliability in specialized domains, enhance reasoning with context, and enable dynamic and interactive knowledge discovery.


Our previous conferences have brought in an average of over 150 attendees each and have featured speakers from organisations including Roche, AstraZeneca, Boehringer Ingelheim, Bayer, Novo Nordisk, and NASA, and many other leading biopharma research leaders. Most recent webinar recordings can be accessed here and some recordings are also available on YouTube.

Jiya Saxena May 28, 2025 09:03 AM Delete

When they are present, you will undoubtedly feel a lot of passion, joy, and satisfaction. You don't have to worry about anything because our Delhi Call Girl is solely focused on your needs and goals

HEY May 26, 2025 10:34 AM Delete

슬롯 RTP 투명성이 뛰어난 다모아 슬롯사이트에서 더 안전하고 즐거운 게임을 경험하세요. 슬롯사이트

ทางเข้า lsm99 May 14, 2025 12:29 AM Delete

I'll immediately seize your rss as I can not find your email subscription link or newsletter service. ทางเข้า lsm99 Do you've any? Please permit me know so that I could subscribe. Thanks.

outdoor spa May 13, 2025 01:01 AM Delete

A hot tub can be a fantastic addition to your home, offering both relaxation and health benefits. Whether you’re looking for a portable outdoor swim spa or a luxurious in-ground model, there are many options to choose from. Hot tubs come in several types, each offering unique features and benefits. The type of hot tub you choose will depend on your needs, budget, and available space. The concept of using hot water for relaxation and healing dates back thousands of years. Ancient civilizations like the Greeks and Romans constructed elaborate bathhouses to take advantage of the therapeutic properties of warm water. Natural hot springs have also been used for centuries, providing people with a natural source of heated, mineral-rich water.

Seth May 08, 2025 06:47 AM Delete

Just wanted to say thank you, MazgTV! I was struggling to find a good stream of the match last night, and your site saved me. The live commentary, HD visuals, and reliable stream made my night. I’ll definitely be recommending this site to all my sports-loving friends. 무료중계

pgzeed ทางเข้า May 07, 2025 01:38 PM Delete

Hello. Great job. I did not expect this. This is a excellent articles. Thanks! pgzeed ทางเข้า

fertari May 01, 2025 10:18 AM Delete

Anyway wonderful work! This is the type of information that should be shared around the internet. สล็อต เว็บ ตรง

bamboo flooring April 30, 2025 08:00 AM Delete

Bamboo floor has high density and low formaldehyde emission. Density of bamboo flooring is 750 kg/m3 for solid and 1100 kg/m3 for strand woven which is much higher than 90% of hardwood species. Formaldehyde emission of bamboo flooring is only 0.015 mg/m3 which is much lower than laminate flooring and engineered wood flooring.

Bamboo flooring has a wide range series like solid, strand woven, engineered, click lock, hand scraped etc. Bamboo floor also has a variety of colors like natural, carbonized, strand natural, strand carbonized, strand tiger. Bamboo is a renewal resource compared with traditional hardwood, the flooring is really green and eco-friendly. The most popular type in the current market is strand woven bamboo flooring which is very suitable for high traffic areas, water resistant and floating floors installation. bamboo flooring price can be by square meter or square foot.

savastan0.cc April 26, 2025 11:16 PM Delete

Very interesting details you have mentioned , thanks for posting . savastan0.cc

Lsm99dna April 23, 2025 03:18 PM Delete

The vacation trades offered are evaluated a variety of in the chosen and simply good value all around the world. Those hostels are normally based towards households which you’ll find accented via charming shores promoting crystal-clear fishing holes, concurrent of one’s Ocean. Hotels Discounts. สมัคร lsm99

nWealth App April 19, 2025 10:37 AM Delete

That is the proper weblog for anyone who desires to search out out about this topic. You realize so much its nearly exhausting to argue with you (not that I truly would need…HaHa). You positively put a brand new spin on a topic thats been written about for years. Nice stuff, simply great! nWealth App

James April 13, 2025 07:49 AM Delete

I found this post incredibly useful. Thank you for the information. I’ll definitely be bookmarking your blog for more updates! learning hebrew for beginners

Julia April 10, 2025 05:31 AM Delete

I really enjoyed this post. Your insights and experiences are incredibly valuable. Keep up the excellent work!
international moving company

Lsm99dna April 05, 2025 04:42 AM Delete

lsm99 สมัคร I accidentally searched and visited your site. I still saw several posts during my visit, but the text was neat and readable. I will quote this post and post it on my blog. Would you like to visit my blog later?

ทางเข้า lsm99 March 27, 2025 04:34 PM Delete

Thank you for another excellent article. Where else could anybody get that kind oof information in such an ideall means of writing? I’ve a presentation next week, and I’m at the look for such info. ทางเข้า lsm99

UFAAUTO789 March 21, 2025 03:31 PM Delete

ufa789 คาสิโนออนไลน์ เว็บตรง สนุกกับเกมสุดฮิต แจ็คพอตแตกทุกวัน

UFAAUTO789 March 21, 2025 03:25 PM Delete

ufa789 แทงบอลง่าย เกมเยอะ โปรเด็ดๆเพียบ

March 20, 2025 04:14 PM Delete

A person essentially assist to make seriously posts I might state. That is the first time I frequented your web page and thus far? I amazed with the research you made to create this particular publish extraordinary. Fantastic process! 카지노커뮤니티

yamataro March 08, 2025 12:25 PM Delete

아로마 출장안마손끝에서 퍼지는 따스한 온기. 가볍게 스치던 터치가 점점 깊어지며 온몸을 감싸 안습니다. 더 나은 휴식을 원한다면, 지금 바로 만나보세요.

yamataro March 08, 2025 12:24 PM Delete

아로마 출장안마손끝에서 퍼지는 따스한 온기. 가볍게 스치던 터치가 점점 깊어지며 온몸을 감싸 안습니다. 더 나은 휴식을 원한다면, 지금 바로 만나보세요.

yamataro March 08, 2025 12:23 PM Delete

아로마 출장안마손끝에서 퍼지는 따스한 온기. 가볍게 스치던 터치가 점점 깊어지며 온몸을 감싸 안습니다. 더 나은 휴식을 원한다면, 지금 바로 만나보세요.

Seth March 03, 2025 06:59 PM Delete

I see that you are using WordPress on your blog, wordpress is the best.;:.:’ omegle alternative

trantongray February 03, 2025 09:35 PM Delete

This is the best blog I have found lateley for the info that I like to read Gold Card TV

___________
This blog is definitely rather handy since I’m at the moment creating an internet floral website – although I am only starting out therefore it’s really fairly small, nothing like this site. Can link to a few of the posts here as they are quite. Thanks much. Zoey Olsen Lipozem Reviews

Angel17 December 21, 2024 01:32 PM Delete

This highlights the powerful combination of large language models and knowledge graphs to enhance data retrieval and decision-making in complex fields like pharmaceuticals and healthcare. worcester plumbers

Add a comment...
Post as (log out)